1. CHEMICAL PRODUCT AND COMPANY INDENTIFICATION
Product: FORMAzol
Cat. No: FO 121
Molecular Research Center
5645 Montgomery Rd.
Cincinnati, Ohio 45212
USA 1-888-841-0900
Product Name: FORMAzol
Chemical Name: A formulation
Molecular Weight: 45.04
Synonyms:
Carbamaldehyde, Methanamide
NFPA RATINGS: (Scale 0-4) Health=2 Fire=1 Reactivity=0 PPE=D*
HMIS RATINGS: (Scale 0-4) Health=2 Fire=1 Reactivity=0
Use chemical fume hood for adequate ventilation.
CHEMTREC EMERGENCY NUMBER Only in the event of an
emergency involving a spill, leak, fire exposure or accident. USA: 1-800-424-9300; International:
1-703-527-3887
2. COMPOSITION AND INFORMATION ON INGREDIENTS
Component CAS
No. EINECS/ELINCS Percent
Formamide 75-12-7 200-842-0 Proprietary
Information
3. HEALTH HAZARD INFORMATION
EFFECTS OF OVEREXPOSURE: May cause respiratory and digestive tract
irritation. May cause eye and skin
irritation. May cause reproductive and
fetal effects. Target organs: Central
nervous system, liver, eyes, reproductive system, skin, mucous membranes.
ROUTES OF ENTRY: Inhalation Yes
Skin Yes
Ingestion Yes
ACUTE EFFECTS
EYE EXPOSURE:
May cause eye irritation, redness and pain.
Eye contact may result in
serious damage to eyes.
SKIN EXPOSURE: May
cause skin irritation and mucus membrane irritation. Symptoms include redness, itching and pain. Harmful if exposed
through skin. Studies have shown that
formamide can be absorbed through the skin in quantities sufficient to produce
systemic toxicity.
INGESTION:
May cause irritation of the digestive tract.
Affects the central nervous system.
May cause headache, dizziness, nausea, vomiting, abdominal pain, and
unconsciousness. May affect
reproductive system.
INHALATION:
May cause respiratory tract irritation.
Symptoms may include coughing and shortness of breath. Inhalation of
high concentrations of vapor may cause central nervous system effects including
headache, dizziness, unconsciousness and coma depending on the duration of
exposure.
CHRONIC EFFECTS
Prolonged and repeated exposure may cause birth
defects including congenital malformation in the fetus. Chronic exposure may cause liver
damage. There is a danger of cumulative
effects.
4. FIRST AID
EYE CONTACT:
Remove any contact lenses. Immediately flush eyes with copious amounts of water
for 15 minutes while lifting upper and lower lids. Get medical attention.
SKIN CONTACT:
Remove contaminated clothing and thoroughly wash and clean items before
reuse. Flush skin with soap and water
for 15 minutes. Get medical treatment
if irritation develops and persists.
INHALATION:
Remove to fresh air. Get medical aid immediately. If not breathing, give
artificial respiration. If breathing is
difficult, give oxygen.
INGESTION:
If victim is conscious, wash mouth out with water. If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Loosen tight
clothing such as collar, tie, belt, etc. Get medical attention immediately.
5. FIRE AND EXPLOSION HAZARD DATA
Emits toxic fumes under fire conditions such as carbon
monoxide, and ammonia. Wear
self-contained breathing apparatus and MSHA/NIOSH approved protective gear.
Flash point: Open
cup 154 C (309 F) Moderate fire hazard
when heated.
Explosion limits: Explosive
mixtures may be formed when heated above the flash point.
Auto-Ignition Temp: 499
C (930 F)
EXTINGUISHING MEDIA: Water spray, water foam, carbon dioxide, dry chemicals. Do not use
water jet. Wear self-contained breathing apparatus or approved respirator. Fires involving formamide will likely
produce very toxic gases that should not be inhaled.
6. ACCIDENTAL RELEASE MEASURES
PERSONAL PROTECTIVE EQUIPMENT: Use gloves, boots, safety glasses, other impervious
clothing to avoid skin contact.
SPILLS OR LEAKS: Ventilate area of leak or spill.
Wear self-contained breathing apparatus and MSHA/NIOSH approved
protective gear. Absorb spill with
earth, sand, vermiculite or other non-combustible material and place in sealed
containers. Do not use combustible
materials such as sawdust and do not flush into sewer.
7. HANDLING AND STORAGE
Use with adequate ventilation and wash hands
thoroughly after handling. Store the
reagent in a cool, dry and well-ventilated area. Refrigeration may be appropriate for long-term storage or
sporadic use. Keep container tightly
closed to avoid exposure. Do not store
in direct sunlight. Empty containers
pose a fire risk, allow residue to evaporate in a fume hood before disposal of
container.
8. EXPOSURE CONTROLS, PERSONAL PROTECTION
PERSONAL PROTECTIVE EQUIPMENT: Wear appropriate eye protection, gloves and lab coat
for routine operations. Do not eat or
drink in area where reagent is used.
Avoid contact with skin and eyes.
Do not breathe vapor. Laboratory
should be equipped with an eye wash station and appropriate exhaust
ventilation. Keep away form oxidizing
agents, acids and alkali.
EXPOSURE LIMITS:
ACGIH: 10 ppm
TWA; Skin-potential significant contribution to overall exposure by the
cutaneous route.
NIOSH: 10 ppm TWA; 15 mg/m3 TWA
9. PHYSICAL AND CHEMICAL PROPERTIES
Description: Clear,
colorless liquid with weak ammonia-like odor
Chemical formula: CH3NO
Molecular weight: 45.04
Melting point: 2.55
C (36.6 F)
Boiling point: 210
C (410 F)
Density 1.132
g/cm3 (water =1)
Vapor pressure: .06
mm Hg @ 25 C
Solubility: Infinitely
soluble with water
Sol. in ethanol, acetone
pH value: 4-5
(20% in water, 20 C)
10. STABILITY AND REACTIVITY
STABILITY: Stable
at room temperature and pressure. Avoid ignition sources, excess heat. Avoid light, moisture and temperatures above
180 C. Keep container tightly closed to
avoid uptake of water from air.
INCOMPATIBILITIES: Aluminum, acids, bases, strong oxidizing agents, calcium nitrate,
iodine, pyridine and sulfur trioxide.
Copper, brass, lead and rubber are attacked by formamide.
HAZARDOUS DECOMPOSITION PRODUCTS: Nitrogen oxides, carbon monoxide and carbon
dioxide. At the boiling point, ammonia,
carbon dioxide and hydrogen cyanide are liberated.
CONDITIONS TO AVOID: Heat, flames
and ignition sources.
11. TOXICOLOGICAL INFORMATION
TOXICITY DATA:
Rat: Oral acute LD50 = 5570mg/kg; Inhalation >3900 ppm / 6h. Mouse: Oral LD50 = 3150 mg/kg. Draize test, rabbit, eye: 100 mg
Severe. Skin rabbit: LD 50 =17 gm /
kg. Investigated as a tumorigen,
mutagen and reproductive effector.
Carcinogenicity: Not listed by ACGIH, IARC, NIOSH, or
OSHA.
Teratogenicity: Embyro or fetus: Death, skin-rat =
1200 mg / kg; stunted fetus growth.
Oral-rat TDLO = 2 g / kg; Specific Developmental Abnormalities:
craniofacial and musculoskeletal, oral-rat TDLO = 7980 mg/kg.
Mutagenicity: RTECS # LQ0525000 for mutation data.
12. ECOLOGICAL INFORMATION
ECOTOXICITY: When released into the soil, formamide may
be biodegradable but it is expected to leach into the ground water. The chemical has an estimated
bioconcentration factor (BCF) of less than 100. When released into the air,
this material is expected to readily degrade by reaction with photochemically
produced hydroxyl radicals with a half-life of less than 1 day. Minnow LC50 =500 mg / L / 48 h.
13. DISPOSAL CONSIDERATIONS
Observe all federal, state and local regulations. US EPA guidelines for the classification
determination are listed in 40 CFR Parts 261.3.
14. TRANSPORT INFORMATION
DOT Not a DOT controlled material (United States).
IMO Not regulated as hazardous material.
IATA Not regulated as hazardous material.
RID/ADR Not regulated as hazardous material.
15. REGULATORY INFORMATION
FEDERAL AND STATE REGULATIONS:
CAS # 75-12-7 can be found on the following state
right to know lists: California, Illinois, Rode Island, Pennsylvania,
Minnesota,
Massachusetts and New Jersey.
OSHA: Hazardous
by definition of Hazard Standard (29 CFR 1910.1200).
TSCA: CAS#75-12-7
TSCA 8(b) inventory: Formamide
TSCA 8(a) PAIR: Formamide
TSCA 8(d) H and S data reporting: Formamide
WHMIS(Canada): CLASS
D-2A: Material causing other toxic effects (very toxic)
SARA CODES: CAS#75-12-7
immediate, delayed.
EINECS NO: 200
842 0
RISK PHRASES: 36/37/38/47
SAFETY PHRASES: 23/26/36/53
16. OTHER INFORMATION Reviewed
by BW, MJ
Creation date 6/30/99
Revision date 2/01/09
This information is believed to be accurate and
represents the information currently available to us. However, we make no
warranty of merchantability or any other warranty, express or implied, with
respect to such information, and we assume no liability resulting from its use.
Users should make their own investigations to determine the suitability of the
information for their particular purposes.
Abbreviations:
N/A Not
Applicable
N.D.A. No data available
TLV-STEL Threshold
Limit Values (Short-Term Exposure Limit)
TLV-TWA Threshold
Limit Values (Time-Weighted Average)
OSHA PEL-TWA OSHA
Permissible Exposure Level